Differential effect of selective D-1 and D-2 dopamine receptor agonists on levodopa-induced dyskinesia in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-exposed monkeys
Identifieur interne : 004454 ( Main/Exploration ); précédent : 004453; suivant : 004455Differential effect of selective D-1 and D-2 dopamine receptor agonists on levodopa-induced dyskinesia in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-exposed monkeys
Auteurs : P. Blanchet [Canada] ; P. J. Bedard [Canada] ; D. R. Britton ; J. W. KebabianSource :
- (The) Journal of pharmacology and experimental therapeutics [ 0022-3565 ] ; 1993.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Singe.
English descriptors
- KwdEn :
- Animal, Animals, Antiparkinson agent, D1 Dopamine receptor, D2 Dopamine receptor, Dopamine (physiology), Dopamine Agents (pharmacology), Dopamine agonist, Dyskinesia, Dyskinesia, Drug-Induced (physiopathology), Female, Levodopa, Levodopa (toxicity), MPTP Poisoning, Macaca fascicularis, Mechanism of action, Monkey, Motor Activity (drug effects), Parkinson Disease (physiopathology), Receptors, Dopamine D1 (drug effects), Receptors, Dopamine D2 (drug effects), Toxicity.
- MESH :
- chemical , drug effects : Receptors, Dopamine D1, Receptors, Dopamine D2.
- chemical , pharmacology : Dopamine Agents.
- chemical , physiology : Dopamine.
- drug effects : Motor Activity.
- physiopathology : Dyskinesia, Drug-Induced, Parkinson Disease.
- chemical , toxicity : Levodopa.
- Animals, Female, MPTP Poisoning, Macaca fascicularis.
Abstract
The motor effects of selective D-1 dopamine receptor stimulation in Parkinson's disease have been explored in a limited number of studies with partial D-1 agonists only and the results were unsatisfactory
Affiliations:
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Le document en format XML
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<front><div type="abstract" xml:lang="en">The motor effects of selective D-1 dopamine receptor stimulation in Parkinson's disease have been explored in a limited number of studies with partial D-1 agonists only and the results were unsatisfactory</div>
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